MUCOADHESIVE IN SITU RECTAL GEL LOADED WITH RIFAMPICIN: STRATEGY TO IMPROVE BIOAVAILABILITY AND ALLEVIATE LIVER TOXICITY

Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity

Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral bioavailability and hepatotoxicity.Rectal mucoadhesive and in situ rectal gels were developed to overcome drug drawbacks.A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios.Based on the drug solubility, the selected ratio was in

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Activities of civic organizations in the field of protection of prisoners and rehabilitated persons in the soviet period legal assessment of russian crimes in Ukraine

Purpose.The purpose of the publication is to reveal the degree of involvement of public institutions in the protection of the rights of prisoners and rehabilitated persons in the Ukrainian SSR in the 1960s-1980s.Methods.The methodological basis of the research was a set of principles of historicism, objectivity, as well as general scientific, speci

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